منابع مشابه
Bacterial gene regulation in diauxic and non-diauxic growth.
When bacteria are grown in a batch culture containing a mixture of two growth-limiting substrates, they exhibit a rich spectrum of substrate consumption patterns including diauxic growth, simultaneous consumption, and bistable growth. In previous work, we showed that a minimal model accounting only for enzyme induction and dilution captures all the substrate consumption patterns [Narang, A., 19...
متن کاملDynamics of glucose-lactose diauxic growth in E. coli
We present a mathematical model of glucose-lactose diauxic growth in Escherichia coli including both the positive and negative regulation mechanisms of the lactose operon as well as the inducer exclusion. To validate this model, we first calculated the time evolution of βgalactosidase for only the lactose nutrient and compared the numerical results with experimental data. Second, we compared th...
متن کاملDynamic flux balance analysis of diauxic growth in Escherichia coli.
Flux Balance Analysis (FBA) has been used in the past to analyze microbial metabolic networks. Typically, FBA is used to study the metabolic flux at a particular steady state of the system. However, there are many situations where the reprogramming of the metabolic network is important. Therefore, the dynamics of these metabolic networks have to be studied. In this paper, we have extended FBA t...
متن کاملIn silico evolution of chemotaxis
Bacteria are able to sense their environment and move towards sources of attractant and away from sources of repellent through the process of chemotaxis. The best understood model for chemotaxis comes from Escherichia coli, where the biochemical pathways have been extensively studied. In E. coli, the bacterium switches between swimming and tumbling based on the changes in the local concentratio...
متن کاملSingle-Cell Dynamics Reveals Sustained Growth during Diauxic Shifts
Stochasticity in gene regulation has been characterized extensively, but how it affects cellular growth and fitness is less clear. We study the growth of E. coli cells as they shift from glucose to lactose metabolism, which is characterized by an obligatory growth arrest in bulk experiments that is termed the lag phase. Here, we follow the growth dynamics of individual cells at minute-resolutio...
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ژورنال
عنوان ژورنال: BMC Evolutionary Biology
سال: 2015
ISSN: 1471-2148
DOI: 10.1186/s12862-015-0492-0